MovDisordV3, Main, Exploration, bibRecord, 002169

Olfactory dysfunction in Parkinsonism caused by PINK1 mutations

Identifieur interne : 002169 ( Main/Exploration ); précédent : 002168; suivant : 002170

Olfactory dysfunction in Parkinsonism caused by PINK1 mutations

Auteurs : Alessandro Ferraris [Italie] ; Tamara Ialongo [Italie] ; Giulio Cesare Passali [Italie] ; Maria Teresa Pellecchia [Italie] ; Livia Brusa [Italie] ; Marianna Laruffa [Italie] ; Arianna Guidubaldi [Italie] ; Gaetano Paludetti [Italie] ; Alberto Albanese [Italie] ; Paolo Barone [Italie] ; Bruno Dallapiccola [Italie] ; Enza Maria Valente [Italie] ; Anna Rita Bentivoglio [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-12-15.

RBID : ISTEX:3854A9AC7C1B5627767B3E444A574C581FD11917

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Mutation, Olfaction, Parkinsonisme, Pathologie du système nerveux, Trouble de l'odorat.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Mutation, Nervous system diseases, Odors, Olfaction, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Olfaction Disorders (genetics), Olfactory disorder, PINK1, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (complications), Parkinsonian Disorders (genetics), Parkinsonism, Protein Kinases (genetics), Sensory Thresholds (physiology), Smell (genetics), Sniffin' sticks, Young Adult, hyposmia, olfaction.
MESH :
- chemical , genetics : Protein Kinases.
- complications : Parkinsonian Disorders.
- diagnosis : Olfaction Disorders.
- etiology : Olfaction Disorders.
- genetics : Olfaction Disorders, Parkinsonian Disorders, Smell.
- physiology : Sensory Thresholds.
- Adolescent, Adult, Aged, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odors, Young Adult.

Abstract

Hyposmia is a common nonmotor feature of Parkinson's disease (PD) and has been variably detected in monogenic Parkinsonisms. To assess olfactory dysfunction in PINK1‐related Parkinsonism, we evaluated olfactory detection threshold, odor discrimination, and odor identification in five groups of subjects: sporadic PD (n = 19), PINK1 homozygous (n = 7), and heterozygous (n = 6) parkinsonian patients, asymptomatic PINK1 heterozygous carriers (n = 12), and Italian healthy subjects (n = 67). All affected subjects and all healthy heterozygotes but one resulted hyposmic, with most patients in the range of functional anosmia or severe hyposmia. Detection threshold was more preserved and discrimination more impaired in patients with PINK1 mutations than in PD cases. Alterations of detection and discrimination were observed also in PINK1 asymptomatic heterozygotes. On the contrary, odor identification appeared to be mostly related to the disease status, as it was impaired in nearly all patients (including PD and PINK1 cases) and preserved in healthy heterozygotes. Our data indicate that olfactory dysfunction is common in PINK1 Parkinsonism and consists typically in defective odor identification and discrimination. A milder olfactory deficit, mostly involving discrimination, can be found in asymptomatic heterozygotes, possibly indicating an underlying preclinical neurodegenerative process. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/3854A9AC7C1B5627767B3E444A574C581FD11917/fulltext/pdf

DOI: 10.1002/mds.22816

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Olfactory dysfunction in Parkinsonism caused by PINK1 mutations</title>
<author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
</author>
<author><name sortKey="Ialongo, Tamara" sort="Ialongo, Tamara" uniqKey="Ialongo T" first="Tamara" last="Ialongo">Tamara Ialongo</name>
</author>
<author><name sortKey="Passali, Giulio Cesare" sort="Passali, Giulio Cesare" uniqKey="Passali G" first="Giulio Cesare" last="Passali">Giulio Cesare Passali</name>
</author>
<author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
</author>
<author><name sortKey="Brusa, Livia" sort="Brusa, Livia" uniqKey="Brusa L" first="Livia" last="Brusa">Livia Brusa</name>
</author>
<author><name sortKey="Laruffa, Marianna" sort="Laruffa, Marianna" uniqKey="Laruffa M" first="Marianna" last="Laruffa">Marianna Laruffa</name>
</author>
<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
</author>
<author><name sortKey="Paludetti, Gaetano" sort="Paludetti, Gaetano" uniqKey="Paludetti G" first="Gaetano" last="Paludetti">Gaetano Paludetti</name>
</author>
<author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
</author>
<author><name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3854A9AC7C1B5627767B3E444A574C581FD11917</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1002/mds.22816</idno>
<idno type="url">https://api.istex.fr/document/3854A9AC7C1B5627767B3E444A574C581FD11917/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C88</idno>
<idno type="wicri:Area/Istex/Curation">000C88</idno>
<idno type="wicri:Area/Istex/Checkpoint">000D71</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Ferraris A:olfactory:dysfunction:in</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19890973</idno>
<idno type="wicri:Area/PubMed/Corpus">001B07</idno>
<idno type="wicri:Area/PubMed/Curation">001B07</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C76</idno>
<idno type="wicri:Area/Ncbi/Merge">002876</idno>
<idno type="wicri:Area/Ncbi/Curation">002876</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002876</idno>
<idno type="wicri:Area/Main/Merge">002A30</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0071259</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C63</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002056</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000D76</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Ferraris A:olfactory:dysfunction:in</idno>
<idno type="wicri:Area/Main/Merge">002E73</idno>
<idno type="wicri:Area/Main/Curation">002169</idno>
<idno type="wicri:Area/Main/Exploration">002169</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Olfactory dysfunction in Parkinsonism caused by PINK1 mutations</title>
<author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>CSS‐Mendel Institute, Casa Sollievo della Sofferenza Hospital, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, Sapienza University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ialongo, Tamara" sort="Ialongo, Tamara" uniqKey="Ialongo T" first="Tamara" last="Ialongo">Tamara Ialongo</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Passali, Giulio Cesare" sort="Passali, Giulio Cesare" uniqKey="Passali G" first="Giulio Cesare" last="Passali">Giulio Cesare Passali</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Otorhinolaryngology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurological Sciences, University Federico II, and IDC‐Herritage‐Capodimonte, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brusa, Livia" sort="Brusa, Livia" uniqKey="Brusa L" first="Livia" last="Brusa">Livia Brusa</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, Sant'Eugenio Hospital, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laruffa, Marianna" sort="Laruffa, Marianna" uniqKey="Laruffa M" first="Marianna" last="Laruffa">Marianna Laruffa</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Otorhinolaryngology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paludetti, Gaetano" sort="Paludetti, Gaetano" uniqKey="Paludetti G" first="Gaetano" last="Paludetti">Gaetano Paludetti</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Otorhinolaryngology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, Carlo Besta Neurological Institute and Catholic University, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurological Sciences, University Federico II, and IDC‐Herritage‐Capodimonte, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>CSS‐Mendel Institute, Casa Sollievo della Sofferenza Hospital, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, Sapienza University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>CSS‐Mendel Institute, Casa Sollievo della Sofferenza Hospital, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina</wicri:regionArea>
<wicri:noRegion>Messina</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Enza Maria Valente, CSS‐Mendel Institute, Viale Regina Margherita 261, Rome 00198, ItalyAnna Rita Bentivoglio, Institute of Neurology, Catholic University, Largo Agostino Gemelli 8, Rome 00168</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Enza Maria Valente, CSS‐Mendel Institute, Viale Regina Margherita 261, Rome 00198, ItalyAnna Rita Bentivoglio, Institute of Neurology, Catholic University, Largo Agostino Gemelli 8, Rome 00168</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-12-15">2009-12-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2350">2350</biblScope>
<biblScope unit="page" to="2357">2357</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">3854A9AC7C1B5627767B3E444A574C581FD11917</idno>
<idno type="DOI">10.1002/mds.22816</idno>
<idno type="ArticleID">MDS22816</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Nervous system diseases</term>
<term>Odors</term>
<term>Olfaction</term>
<term>Olfaction Disorders (diagnosis)</term>
<term>Olfaction Disorders (etiology)</term>
<term>Olfaction Disorders (genetics)</term>
<term>Olfactory disorder</term>
<term>PINK1</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonism</term>
<term>Protein Kinases (genetics)</term>
<term>Sensory Thresholds (physiology)</term>
<term>Smell (genetics)</term>
<term>Sniffin' sticks</term>
<term>Young Adult</term>
<term>hyposmia</term>
<term>olfaction</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Olfaction Disorders</term>
<term>Parkinsonian Disorders</term>
<term>Smell</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sensory Thresholds</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Mutation</term>
<term>Olfaction</term>
<term>Parkinsonisme</term>
<term>Pathologie du   système nerveux</term>
<term>Trouble de l'odorat</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Hyposmia is a common nonmotor feature of Parkinson's disease (PD) and has been variably detected in monogenic Parkinsonisms. To assess olfactory dysfunction in PINK1‐related Parkinsonism, we evaluated olfactory detection threshold, odor discrimination, and odor identification in five groups of subjects: sporadic PD (n = 19), PINK1 homozygous (n = 7), and heterozygous (n = 6) parkinsonian patients, asymptomatic PINK1 heterozygous carriers (n = 12), and Italian healthy subjects (n = 67). All affected subjects and all healthy heterozygotes but one resulted hyposmic, with most patients in the range of functional anosmia or severe hyposmia. Detection threshold was more preserved and discrimination more impaired in patients with PINK1 mutations than in PD cases. Alterations of detection and discrimination were observed also in PINK1 asymptomatic heterozygotes. On the contrary, odor identification appeared to be mostly related to the disease status, as it was impaired in nearly all patients (including PD and PINK1 cases) and preserved in healthy heterozygotes. Our data indicate that olfactory dysfunction is common in PINK1 Parkinsonism and consists typically in defective odor identification and discrimination. A milder olfactory deficit, mostly involving discrimination, can be found in asymptomatic heterozygotes, possibly indicating an underlying preclinical neurodegenerative process. © 2009 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
<li>Lombardie</li>
</region>
<settlement><li>Milan</li>
<li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Latium"><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
</region>
<name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<name sortKey="Brusa, Livia" sort="Brusa, Livia" uniqKey="Brusa L" first="Livia" last="Brusa">Livia Brusa</name>
<name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name>
<name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name>
<name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
<name sortKey="Guidubaldi, Arianna" sort="Guidubaldi, Arianna" uniqKey="Guidubaldi A" first="Arianna" last="Guidubaldi">Arianna Guidubaldi</name>
<name sortKey="Ialongo, Tamara" sort="Ialongo, Tamara" uniqKey="Ialongo T" first="Tamara" last="Ialongo">Tamara Ialongo</name>
<name sortKey="Laruffa, Marianna" sort="Laruffa, Marianna" uniqKey="Laruffa M" first="Marianna" last="Laruffa">Marianna Laruffa</name>
<name sortKey="Paludetti, Gaetano" sort="Paludetti, Gaetano" uniqKey="Paludetti G" first="Gaetano" last="Paludetti">Gaetano Paludetti</name>
<name sortKey="Passali, Giulio Cesare" sort="Passali, Giulio Cesare" uniqKey="Passali G" first="Giulio Cesare" last="Passali">Giulio Cesare Passali</name>
<name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
<name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002169 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002169 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:3854A9AC7C1B5627767B3E444A574C581FD11917
   |texte=   Olfactory dysfunction in Parkinsonism caused by PINK1 mutations
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Olfactory dysfunction in Parkinsonism caused by PINK1 mutations

Olfactory dysfunction in Parkinsonism caused by PINK1 mutations

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.